Abstract Title:

Exposure to bisphenol A: current levels from food intake are toxic to human cells.

Abstract Source:

Mol Biol Rep. 2019 Feb 7. Epub 2019 Feb 7. PMID: 30734171

Abstract Author(s):

Karla L Hernández-Hernández, Natalia Tapia-Orozco, Miquel Gimeno, Ana María Espinosa-García, José Antonio García-García, Daniela Araiza-Olivera, Francisco Sánchez-Bartez, Isabel Gracia-Mora, Manuel Gutierrez-Aguilar, Roeb García-Arrazola

Article Affiliation:

Karla L Hernández-Hernández


In the present work, cell lines of different origin were exposed to BPA levels from food intake reported elsewhere. Specifically, we used an in vitro assay to determine cytotoxicity of BPA in three cell lines: MCF7 (breast cancer), PC3 (prostate cancer) and 3T3-L1 (mouse fibroblast). Cytotoxic effects were observed at concentrations higher than 50 μg/mL which is above the involuntary exposure level of BPA described before in fresh, canned and frozen foods and beverages. Furthermore, medial inhibitory concentrations (IC50) of 85.17 μg/mL and 88.48 μg/mL were observed for PC3 and 3T3-L1, respectively, and a slightly lower IC50 of 64.67 μg/mL for MCF7. These results highlight BPA's toxicity potential at current levels from food intake. The cell line-dependent divergent response to BPA reported herein is discussed.

Study Type : Human In Vitro
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