Abstract Title:

Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: restoration of dopaminergic and cholinergic system and oxidative stress indicators.

Abstract Source:

Chem Biol Interact. 2021 Mar 11:109431. Epub 2021 Mar 11. PMID: 33716020

Abstract Author(s):

Eliana Jardim Fernandes, Marcia Rósula Poetini, Magna Sotelo Barrientos, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Elize Aparecida Santos Musachio, Amarilis Santos De Carvalho, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Bruna Piaia Ramborger, Rafael Roehrs, Marina Prigol, Gustavo Petri Guerra

Article Affiliation:

Eliana Jardim Fernandes


Parkinson's is a neurodegenerative disease, characterized by the loss of dopaminergic neurons, cholinergic alterations and oxidative damages. Lutein is widely known by its antioxidants properties. In the present study, we investigated whether lutein-loaded nanoparticles protects against locomotor damage and neurotoxicity induced by Parkinson's disease model in Drosophila melanogaster, as well as possible mechanisms of action. First, the nanoparticles were characterized by physicochemical methods, demonstrating that water affinity was improved by the encapsulation of lutein into the polymeric encapsulant matrix. The fruit flies of 1-4 days old were divided into four groups and exposed to a standard diet (control), a diet containing either rotenone (500μM), lutein-loaded nanoparticles (6 μM) or rotenone (500 μM) and lutein-loaded nanoparticles (6 μM) for 7 days. The survival percentage was assessed, the flies were submitted to negative geotaxis, open field tasks and the determination of dopamine levels, acetylcholinesterase activity and oxidative stress indicators (superoxide dismutase, catalase, thiobarbituric acid reactive substances and glutathione S-transferase) were carried out. The exposure to lutein-loaded nanoparticles protected against locomotor damage and the decrease survival rate induced by rotenone, besides, it restored thedopamine levels, acetylcholinesterase activity and oxidative stress indicators. These results provide evidence that lutein-loaded nanoparticles are an alternative treatment for rotenone-induced damage, and suggest the involvement of dopaminergic and cholinergic system and oxidative stress.

Study Type : Insect Study

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