Abstract Title:

Oxidative injury caused by individual and combined exposure of neonicotinoid, organophosphate and herbicide in zebrafish.

Abstract Source:

Toxicol Rep. 2017 ;4:240-244. Epub 2017 May 17. PMID: 28959645

Abstract Author(s):

Saurabh Shukla, Reena C Jhamtani, M S Dahiya, Rakhi Agarwal

Article Affiliation:

Saurabh Shukla


The greatest challenge in environmental toxicology is to understand the effects of mixture toxicity as environmental pollutants co-exist and exhibit combined effects. Thus, it is necessary to evaluate the mixture toxicity associated with two or more co-existing compounds. Pesticides are widely used to control pest, they are ubiquitous in nature and present in all environmental components. Pesticide residue can be detected in almost all components of environment and food samples. Imidacloprid (IMD) (neonicotinoid), dichlorvos (DIC) (organophosphate) and atrazine (ATZ) are three widely used pesticides for commercial uses. Present work includes the assessment of effects of individual exposure of IMD (27.5 mg/L), DIC (15 mg/L), and ATZ (03 mg/L) and in combination of three (CMD) (13.75 + 7.5 + 1.5 mg/L IMD, DIC&ATZ, respectively) in terms of LPO, GSH content and antioxidant enzymes activities (superoxide dismutase, catalase and glutathione peroxidase) in zebrafish (Danio rerio), exposed for 24 h. CMD group exhibits highest lipid peroxidation than other individually exposed groups. Similarly, the activities of antioxidant enzymes were highest in CMD group with reduced GSH content. Results indicate that exposure to mixture of pesticides develops synergistic effects which were more toxic in compare to individual exposure and also produce toxicity in all examined tissues rather than selective organ toxicity.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.