Abstract Title:

Organochlorine compounds, iodine intake, and thyroid hormone levels during pregnancy.

Abstract Source:

Environ Sci Technol. 2009 Oct 15;43(20):7909-15. PMID: 19921913

Abstract Author(s):

Mar Alvarez-Pedrerol, Monica Guxens, Jesús Ibarluzea, Marisa Rebagliato, Agueda Rodriguez, Mercedes Espada, Fernando Goñi, Mikel Basterrechea, Jordi Sunyer

Article Affiliation:

Centre for Research in Environmental Epidemiology, Barcelona, Spain. [email protected]


The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa (n = 570), Spain. Thyroid hormones (free T4 and total T3), thyrotropin, and polychlorinated biphenyls (PCB congeners 118, 138, 153, and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), dichlorodiphenyl dichloroethylene (p'p'-DDE) and dichlorodiphenyl richloroethane (p'p-DDT) were measured in serum samples collected at first trimester of pregnancy. Urinary iodine concentration (UIC) was measured and iodine intake from diet, iodized salt, and supplements were estimated from a food frequency questionnaire. Levels of HCB and PCBs congeners 180, 153, and 138 were related to lowe rtotal T3 levels (adjusted coefficient (SE): -4.0(1.1), -6.1(1.6), -5.5(1.6), and 3.8(1.4), respectively) and higher free T4 levels (adjusted coefficient (SE): 0.013(0.05), 0.017(0.007), 0.016(0.007), and 0.007(0.006), respectively). These associations were homogeneous in both cohorts, especially for PCBs and total T3 (p-value forthe interaction between cohorts>0.8). Iodine intake and UIC did not affect the association between OCs and thyroid hormones. Our results indicate that exposure to OCs during pregnancy can alter TH levels.

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