n/a
Abstract Title:

The Australian Child Health and Air Pollution Study (ACHAPS): A national population-based cross-sectional study of long-term exposure to outdoor air pollution, asthma, and lung function.

Abstract Source:

Environ Int. 2018 Aug 17 ;120:394-403. Epub 2018 Aug 17. PMID: 30125857

Abstract Author(s):

Luke D Knibbs, Adriana M Cortés de Waterman, Brett G Toelle, Yuming Guo, Lyn Denison, Bin Jalaludin, Guy B Marks, Gail M Williams

Article Affiliation:

Luke D Knibbs

Abstract:

Most studies of long-term air pollution exposure and children's respiratory health have been performed in urban locations with moderate pollution levels. We assessed the effect of outdoor nitrogen dioxide (NO), as a proxy for urban air pollution, on current asthma and lung function in Australia, a low-pollution setting. We undertook a national population-based cross-sectional study of children aged 7-11 years living in 12 Australian cities. We collected information on asthma symptoms from parents via questionnaire and measured children's lung function (forced expiratory volume in 1 s [FEV], forced vital capacity [FVC]) and fractional exhaled nitric oxide [Fe]). We estimated recent NOexposure (last 12 months) using monitors near each child's school, and used a satellite-based land-use regression (LUR) model to estimate NOat each child's school and home. Our analysis comprised 2630 children, among whom the prevalence of current asthma was 14.9%. Mean (±SD) NOexposure was 8.8 ppb (±3.2) and 8.8 ppb (±2.3) for monitor- and LUR-based estimates, respectively. Mean percent predicted post-bronchodilator FEVand FVC were 101.7% (±10.5) and 98.8% (±10.5), respectively. The geometric mean Feconcentration was 9.4 ppb (±7.1). An IQR increase in NO(4.0 ppb) was significantly associated with increased odds of having current asthma; odds ratios (ORs) were 1.24 (95% CI: 1.08, 1.43) and 1.54 (95% CI: 1.26, 1.87) for monitor- and LUR-based estimates, respectively. Increased NOexposure was significantly associated with decreased percent predicted FEV(-1.35 percentage points [95% CI: -2.21, -0.49]) and FVC (-1.19 percentage points [95% CI: -2.04, -0.35], and an increase in Feof 71% (95% CI: 38%, 112%). Exposure to outdoor NOwas associated with adverse respiratory health effects in this population-based sample of Australian children. The relatively low NOlevels at which these effects were observed highlight the potential benefits of continuous exposure reduction.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.