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Article Publish Status: FREE
Abstract Title:

Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice.

Abstract Source:

iScience. 2022 Dec 22 ;25(12):105479. Epub 2022 Nov 2. PMID: 36338436

Abstract Author(s):

Feng-Xia Gao, Rui-Xin Wu, Mei-Ying Shen, Jing-Jing Huang, Ting-Ting Li, Chao Hu, Fei-Yang Luo, Shu-Yi Song, Song Mu, Ya-Nan Hao, Xiao-Jian Han, Ying-Ming Wang, Luo Li, Sheng-Long Li, Qian Chen, Wang Wang, Ai-Shun Jin

Article Affiliation:

Feng-Xia Gao

Abstract:

The repetitive applications of vaccine boosters have been brought up in face of continuous emergence of SARS-CoV-2 variants with neutralization escape mutations, but their protective efficacy and potential adverse effects remain largely unknown. Here, we compared the humoral and cellular immune responses of an extended course of recombinant receptor binding domain (RBD) vaccine boosters with those from conventional immunization strategy in a Balb/c mice model. Multiple vaccine boosters after the conventional vaccination course significantly decreased RBD-specific antibody titers and serum neutralizing efficacy against the Delta and Omicron variants, and profoundly impaired CD4and CD8T cell activation and increased PD-1 and LAG-3 expressions in these T cells. Mechanistically, we confirmed that extended vaccination with RBD boosters overturned the protective immune memories by promoting adaptive immune tolerance. Our findings demonstrate potential risks with the continuous use of SARS-CoV-2 vaccine boosters, providing immediate implications for the global COVID-19 vaccination enhancement strategies.

Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Immunosuppressive : CK(289) : AC(55)

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