Abstract Title:

Anticataractogenic effect of an extract of the oyster mushroom, Pleurotus ostreatus, in an experimental animal model.

Abstract Source:

J Trop Pediatr. 2000 Apr;46(2):92-6. PMID: 19373574

Abstract Author(s):

M Isai, R Elanchezhian, M Sakthivel, A Chinnakkaruppan, M Rajamohan, C Nelson Jesudasan, P A Thomas, P Geraldine


PURPOSE: To evaluate the efficacy of Pleurotus ostreatus extract in preventing selenite-induced cataractogenesis. METHODS: In vitro, enucleated rat lenses, divided into one control and three experimental groups (selenite only, simultaneous selenite and extract, initial extract and subsequent selenite), underwent morphological and biochemical evaluation. The anti-cataractogenic effect was also evaluated in vivo. RESULTS: In vitro, simultaneous incubation of extract with selenite-challenged lenses caused a decrease in lens opacification by maintaining antioxidant components at near normal levels. In vivo, P.ostreatus (300 mg/kg body weight) prevented cataract in 75% of rats. CONCLUSION: Extract of P. ostreatus prevents experimental selenite-induced cataractogenesis.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)

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