Article Publish Status: FREE
Abstract Title:

[Screening of the anti-tumor active fraction from Ipomoea batatas Lam. (cv.simon) leaves].

Abstract Source:

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 May ;40(5):499-503. PMID: 26032078

Abstract Author(s):

Shuhe Lü, Cong Lin, Pingsheng Xu

Article Affiliation:

Shuhe Lü


OBJECTIVE: Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated.

METHODS: The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respectively.

RESULTS: The three fractions all showed anti-tumor activities in three cancer cells with different sensitivity. Among them, SM-B was the most potent fraction with IC50 values at 15.17 mg/L, 72.64 mg/L or 165.47 mg/L in MGC803 cells, A549 cells or Hep3B cells, respectively (P<0.05).

CONCLUSION: Th e extraction of Brazil sweet potato leaves displayed anti-tumor activity and SM-B was the most potent fraction.

Study Type : In Vitro Study

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