An extract of sweet potato leaves displayed anti-tumor activity in vitro. - GreenMedInfo Summary

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Abstract Title:

[Screening of the anti-tumor active fraction from Ipomoea batatas Lam. (cv.simon) leaves].

Abstract Source:

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 May ;40(5):499-503. PMID: 26032078

Abstract Author(s):

Shuhe Lü, Cong Lin, Pingsheng Xu

Article Affiliation:

Shuhe Lü

Abstract:

OBJECTIVE: Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated.

METHODS: The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respectively.

RESULTS: The three fractions all showed anti-tumor activities in three cancer cells with different sensitivity. Among them, SM-B was the most potent fraction with IC50 values at 15.17 mg/L, 72.64 mg/L or 165.47 mg/L in MGC803 cells, A549 cells or Hep3B cells, respectively (P<0.05).

CONCLUSION: Th e extraction of Brazil sweet potato leaves displayed anti-tumor activity and SM-B was the most potent fraction.

Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sweet Potato : CK(186) : AC(100)
Diseases : Gastric Cancer : CK(1165) : AC(689), Liver Cancer : CK(2460) : AC(1555), Lung Cancer : CK(2308) : AC(1333)
Pharmacological Actions : Cytotoxic : CK(272) : AC(231)
Additional Keywords : Dose Response : CK(1769) : AC(699), Plant Extracts : CK(17959) : AC(6472)

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Key Research Topics

Disease

Liver Cancer
Lung Cancer
Gastric Cancer

Substance

Sweet Potato

Pharmacological Actions

Cytotoxic

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