Article Publish Status: FREE
Abstract Title:

Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus.

Abstract Source:

Arch Pharm Res. 2014 ;37(9):1117-23. Epub 2014 Jan 7. PMID: 24395532

Abstract Author(s):

Shu-Jen Chang, Su-Hua Huang, Ying-Ju Lin, Yi-Yun Tsou, Cheng-Wen Lin

Article Affiliation:

Shu-Jen Chang


Rheum palmatum, Chinese traditional herb, exhibits a great variety of anti-cancer and anti-viruses properties. This study rates antiviral activity of R. palmatum extracts and its components against Japanese encephalitis virus (JEV) in vitro. Methanol extract of R. palmatum contained higher levels of aloe emodin, chrysophanol, rhein, emodin and physcion than water extract. Methanol extract (IC₅₀ = 15.04 μg/ml) exhibited more potent inhibitory effects on JEV plaque reduction than water extract (IC₅₀ = 51.41 μg/ml). Meanwhile, IC₅₀ values determined by plaque reduction assay were 15.82 μg/ml for chrysophanol and 17.39 μg/ml for aloe-emodin, respectively. Virucidal activityof agents correlated with anti-JEV activity, while virucidal IC₅₀ values were 7.58 μg/ml for methanol extract, 17.36 μg/ml for water extract, 0.75 μg/ml for chrysophanol and 0.46 μg/ml for aloe-emodin, respectively. In addition, 10 μg/ml of extract, chrysophanol or aloe emodin caused 90 % inhibition of JEV yields in cells and significantly activated gamma activated sequence-driven promoters. Hence, methanol extract of R. palmatum and chrysophanol with high therapeutic index might be useful for development of antiviral agents against JEV.

Study Type : In Vitro Study

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