Abstract Title:

Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields.

Abstract Source:

Biochem Biophys Res Commun. 2005 Jun 24 ;332(1):28-32. PMID: 15896294

Abstract Author(s):

Tomonori Sakurai, Shin Koyama, Yoshiki Komatsubara, Wang Jin, Junji Miyakoshi

Article Affiliation:

Tomonori Sakurai


We evaluated the effects of extremely low frequency magnetic field (ELFMF) on glucose-stimulated insulin secretion from HIT-T15 cells and investigated the mechanisms of these effects. We demonstrated that exposure to ELFMF at 5mT decreased glucose-stimulated insulin secretion by preventing the increases in cellular adenosine 5'-triphosphate/adenosine 5'-diphosphate, membrane depolarization, and cytosolic free calcium ion concentration. The glucose-induced upregulation of insulin mRNA expression was also attenuated by exposure to ELFMF, although cell viability was not affected. These findings demonstrate the potential of exposure to ELFMF for clinical use as a novel inhibitory method of insulin secretion.

Study Type : Human In Vitro

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