Article Publish Status: FREE
Abstract Title:

Fenugreek (L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice.

Abstract Source:

Nutrients. 2020 Aug 24 ;12(9). Epub 2020 Aug 24. PMID: 32846876

Abstract Author(s):

Devesh Tewari, Artur Jóźwik, Małgorzata Łysek-Gładysińska, Weronika Grzybek, Wioletta Adamus-Białek, Jacek Bicki, Nina Strzałkowska, Agnieszka Kamińska, Olaf K Horbańczuk, Atanas G Atanasov

Article Affiliation:

Devesh Tewari


Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (<0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice.

Study Type : Animal Study

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