Abstract Title:

Effect of Fenugreek Seeds Powder (Trigonella foenum-graecum L.) on Experimental Induced Hyperlipidemia in Rabbits.

Abstract Source:

J Diet Suppl. 2016 Apr 12:1-8. Epub 2016 Apr 12. PMID: 27070043

Abstract Author(s):

Megh Shyam Sharma, Prema Ram Choudhary

Article Affiliation:

Megh Shyam Sharma


In the present experimental study, the effect of Trigonella foenum-graecum L. (TFG) seeds powder on experimentally induced hyperlipidemia in rabbits was investigated. Twenty albino rabbits were randomly, equally divided into two groups and fed pure cholesterol (0.5g/kg body weight/day) for the period of eight weeks to develop hyperlipidemia. Group-I (control) and Group-II received a normal diet with 2 mL normal saline and 2 mL aqueous emulsified TFG seeds powder (500 mg/kg body weight/day) for four weeks, respectively. Lipid profile and weight were measured at baseline after eight weeks and at the end of the study (12 weeks). Atherogenic indices were calculated by Friedewalds formula. Statistical analysis was performed using IBM: SPSS version 20, and student t test was used to compare variables between groups. After eight weeks of study period, cholesterol feeding was discontinued and hyperlipidemic value was compared with the initial baseline data. Significant increase in body weight and lipid profile variables were observed in the two groups, while there was a significant decrease in high-density lipoprotein cholesterol (HDL-C). After the end of the study (12 weeks), the aqueous emulsified fenugreek (TFG) seeds powder reduced significantly the serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and the atheriogenic index (P<0.001), with significant increase in the HDL-C (P<0.001) in experimentally hyperlipidemic rabbits (P<0.001) as compared to control group, whereas no significant differences were observed in the triglyceride very low-density lipoprotein cholesterol (VLDL-C) and body weight (P>0.05) of both groups. It was concluded that fenugreek seeds powder had a significant hypolipidemic effect in experimentally-induced hyperlipidemic rabbits.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.