Abstract Title:

Fermented camel milk by Lactococcus lactis subsp. cremoris attenuates erythrocytes oxidative stress-induced hematological and immunological damage in CCl-intoxicated mice.

Abstract Source:

Environ Sci Pollut Res Int. 2018 Sep ;25(26):25983-25993. Epub 2018 Jul 2. PMID: 29968212

Abstract Author(s):

Houda Hamed, Fatma Chaari, Zied Ghannoudi, Kaouther Dhouib, Semia Chaabouni, Abdelfattah El Feki, Ahmed Gargouri

Article Affiliation:

Houda Hamed


Fermented camel by Lactococcus lactis subsp. cremoris has been recently discovered to protect against the toxic effect of carbon tetrachloride (CCl), but its beneficial effects in the presence of oxidative stress in the erythrocytes have not been established. In the present study, 28 mice were randomly divided into four groups: control group; CClgroup: intoxicated by a single intraperitoneal injection (ip) of CCl; group FCM-LLC + CCl: pretreated with FCM-LLC daily during 14 days, and received a single dose of CCl. FCM-LLC group received FCM-LLC alone. The occurrence of oxidative stress in erythrocytes was evidenced by an increase in lipid peroxidation, protein carbonyl, and changes in antioxidant enzyme activities and non-enzymatic antioxidant. The oxidative injury induced by CClin the erythrocytes was confirmed by modifications in hematological parameters and decreases in protein, albumin, and globulin content in the serum of intoxicated mice. Therefore, CClcaused a significant decrease in immunotoxic indices, including immunoglobulin G (IgG), immunoglobulin M (Ig M), and immunoglobulin A (IgA) levels, and an increase of inflammatory markers such as C-reactive protein (CRP) level. Meanwhile, FCM-LLC effectively restored the parameters cited above to near-normal values. It can be suggested that fermented camel milk could regulate deviant physiological effects induced by CClwhich is due to its powerful antioxidant and immunomodulatory and anti-inflammatory capacity.

Study Type : Animal Study

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