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Article Publish Status: FREE
Abstract Title:

FermentedL. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury.

Abstract Source:

Nutrients. 2019 Jan 23 ;11(2). Epub 2019 Jan 23. PMID: 30678049

Abstract Author(s):

Raffaella Di Cagno, Pasquale Filannino, Olimpia Vincentini, Vincenzo Cantatore, Ivana Cavoski, Marco Gobbetti

Article Affiliation:

Raffaella Di Cagno

Abstract:

L. contains high level of nutrients and biologically active compounds. Recently, lactic fermentation has been proposed as a biotechnological option to enrich the profile of biogenic compounds ofL. puree. This study investigated the capability of fermentation by selected lactic acid bacteria to enhance the restoring features ofjuice towards intestinal inflammation and epithelial injury. Lactic acid fermentation markedly increased the total antioxidant capacity ofjuice, preserved the inherent levels of vitamins C, A, and E, and increased the bioavailability of the level of vitamin B₂ and that of phenolics. The effects of fermentedjuice on a Caco-2 cell line were investigated using an in vitro model closest to the in vivo conditions. Fermentedjuice strongly decreased the levels of pro-inflammatory mediators and reactive oxygen species. It also counteracted the disruption of the Caco-2 cell monolayers treated with the inflammatory stimulus. We used a diversified spectrum of lactic acid bacteria species, and some effects appeared to be strains- or species-specific. Fermentation withB7 ensured the best combination for the content of bioactive compounds and the ability to counteract the intestinal inflammation and epithelial injury.

Study Type : In Vitro Study

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Sayer Ji
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