Abstract Title:

Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up.

Abstract Source:

Clin Exp Rheumatol. 2006 May-Jun;24(3):325-8. PMID: 18771352

Abstract Author(s):

Lev V Demidov, Ljudmila V Manziuk, Galina Y Kharkevitch, Nina A Pirogova, Elena V Artamonova


OBJECTIVE: To investigate the effect of the fermented wheat germ extract (Avemar)in patients with severe rheumatoid arthritis (RA). METHODS: Fifteen female RA (Steinbrocker II-III) patients, who had unsuccessfully tried two different DMARD treatments, were enrolled in an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (HAQ) and the assessment of morning stiffness were applied. Patients were evaluated at baseline, 6 and 12 months. For statistical analyses the Wilcoxon test was used.RESULTS: At both 6 and 12 months, Ritchie index, HAQ and morning stiffness showed significant improvements compared with the baseline values. Dosages of steroids could be reduced in about half of the patients. No side effects of Avemar wereobserved.CONCLUSION: Supplementation of standard therapies with a continuous administration of Avemar is beneficial for RA patients.

Study Type : Human Study

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