Abstract Title:

Adjunctive Berberine Reduces Antipsychotic-Associated Weight Gain and Metabolic Syndrome in Patients with Schizophrenia: A Randomized Controlled Trial.

Abstract Source:

Psychiatry Clin Neurosci. 2021 Dec 21. Epub 2021 Dec 21. PMID: 34931749

Abstract Author(s):

Mei Yan Chan, Zongshi Qin, Sui-Cheung Man, Ming Lam, Wing Him Lai, Roger Man Kin Ng, Che Kin Lee, Tak Luen Wong, Edwin Ho Ming Lee, Hei Kiu Wong, Yibin Feng, Lanying Liu, Feng Han, Eric Yu Hai Chen, Zhang-Jin Zhang

Article Affiliation:

Mei Yan Chan


AIM: To evaluate the efficacy and safety of berberine as an adjuvant in treating antipsychotic-associated weight gain and metabolic syndrome (MetS).

METHODS: One hundred and thirteen participants with schizophrenia spectrum disorders who had developed MetS were recruited. They were randomly assigned to berberine (600 mg/day, n=58) or placebo (n=55) groups for 12 weeks. The primary outcome was the change from baseline to week 12 in net weight. Secondary outcomes included body mass index (BMI), waist circumference, serum glucose and lipid profiles, and the severity of psychotic symptoms.

RESULTS: Compared with the placebo group, the berberine group showed a significantly greater reduction in weight gain at 9 weeks (mean difference [MD]=-0.75, 95% confidence interval [CI]: -1.42 to -0.07, P=0.031, d=0.41) and 12 weeks (MD=-1.08, 95% CI: -1.76 to -0.40, P=0.002, d=0.59). Patients who received berberine also showed statistically significant improvements in endpoint in BMI (MD=-0.41, 95% CI: -0.65 to -0.17, P=0.001, d=0.64), total cholesterol (MD=-0.58, 95% CI: -0.74 to -0.41, P<.001, d=1.31), low-density lipoprotein (MD=-0.52, 95% CI: -0.68 to -0.35, P<.001, d=1.19), and glycated hemoglobin (MD=-0.09, 95% CI: -0.18 to 0, P=0.05, d=0.37). Berberine was well tolerated without serious adverse events and aggravation of psychotic symptoms compared with placebo.

CONCLUSIONS: Findings suggest that berberine is effective in attenuating antipsychotic-associated weight gain and MetS. This article is protected by copyright. All rights reserved.

Study Type : Human Study

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Sayer Ji
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