Article Publish Status: FREE
Abstract Title:

Harnessing the antibacterial activity ofandagainst antibiotic-resistantTyphi andEnteritidis of poultry origin.

Abstract Source:

Vet World. 2020 Jul ;13(7):1388-1396. Epub 2020 Jul 21. PMID: 32848315

Abstract Author(s):

Amruta Nair, T Balasaravanan, Sunil Jadhav, Vysakh Mohan, Chethan Kumar

Article Affiliation:

Amruta Nair


Background and Aim: In a scenario of the ineffectiveness of the current drugs against antibiotic-resistant pathogens, the herbal extracts can serve as an alternative remedy. This study appraises the antibacterial potency of(gall),(fruit) individually and synergistically against antimicrobial-resistant (AMR)Typhi andEnteritidis in a time and dose-dependent manner. Further, the antibacterial phytocompounds were identified employing gas chromatography-mass spectrometry (GC-MS).

Materials and Methods: Preliminary antibacterial activity of the plant extracts was assessed using the agar disk diffusion method.evaluations ofmethanolic extract (QIME) andmethanolic extract (PEME) against. Typhi and. Enteritidis were carried out using plate count method.

Results: QIME and PEME at a dose rate of 50 mg/ml and 25 mg/ml, respectively, had a complete bactericidal effect on AMR. Typhi and. Enteritidis whereas 10 logCFU/ml of exponential growth was seen in untreated control groups. At the lower concentrations, QIME and PEME had a significant bacteriostatic effect (3-6 logreduction of the test isolates). The synergistic antibacterial effect obtained from the combination of these two plant extracts at 12.5 mg/ml was superior (p<0.001) than the individual treatments. Phytochemical profiling indicated the presence of tannins, flavonoids, saponins, and terpenoids in both the plant extracts. GC-MS analysis of QIME and PEME revealed the presence of 16 and 15 antibacterial phytocompounds, respectively. Further 1, 2, 3 Benzenetriol was found as the prominent active principle.

Conclusion: The findings validate that QIME and PEME are potential antibacterial agents against AMR. Typhi,. Enteritidis and can play a promising role in antimicrobial packaging, poultry feed additives and can also serve as a platform for formulating effective phytotherapeutics.

Study Type : In Vitro Study

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