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Article Publish Status: FREE
Abstract Title:

First evidence that Ecklonia cava-derived dieckol attenuates MCF-7 human breast carcinoma cell migration.

Abstract Source:

Mar Drugs. 2015 Mar 30 ;13(4):1785-97. Epub 2015 Mar 30. PMID: 25830682

Abstract Author(s):

Eun-Kyung Kim, Yujiao Tang, Yon-Suk Kim, Jin-Woo Hwang, Eun-Ju Choi, Ji-Hyeok Lee, Seung-Hong Lee, You-Jin Jeon, Pyo-Jam Park

Article Affiliation:

Eun-Kyung Kim

Abstract:

We investigated the effect of Ecklonia cava (E. cava)-derived dieckol on movement behavior and the expression of migration-related genes in MCF-7 human breast cancer cell. Phlorotannins (e.g., dieckol, 6,6'-biecko, and 2,7″-phloroglucinol-6,6'-bieckol) were purified from E. cava by using centrifugal partition chromatography. Among the phlorotannins, we found that dieckol inhibited breast cancer cell the most and was selected for further study. Radius™-well was used to assess cell migration, and dieckol (1-100 µM) was found to suppress breast cancer cell movement. Metastasis-related gene expressions were evaluated by RT-PCR and Western blot analysis. In addition, dieckol inhibited the expression of migration-related genes such as matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF). On the other hand, it stimulated the expression of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. These results suggest that dieckol exerts anti-breast cancer activity via the regulation of the expressions of metastasis-related genes, and this is the first report on the anti-breast cancer effect of dieckol.

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