Abstract Title:

Effect of fish and krill oil supplementation on glucose tolerance in rabbits with experimentally induced obesity.

Abstract Source:

Eur J Nutr. 2015 Oct ;54(7):1055-67. Epub 2014 Oct 15. PMID: 25315197

Abstract Author(s):

Zhenya Ivanova, Bodil Bjørndal, Natalia Grigorova, Anton Roussenov, Ekaterina Vachkova, Kjetil Berge, Lena Burri, Rolf Berge, Spaska Stanilova, Anelia Milanova, Georgi Penchev, Rita Vik, Vladimir Petrov, Teodora Mircheva Georgieva, Boycho Bivolraski, Ivan Penchev Georgiev

Article Affiliation:

Zhenya Ivanova


PURPOSE: This study was conducted to investigate the effect of fish oil (FO) and krill oil (KO) supplementation on glucose tolerance in obese New Zealand white rabbits.

METHODS: The experiments were carried out with 24 male rabbits randomly divided into four groups: KO-castrated, treated with KO; FO-castrated, treated with FO; C-castrated, non-treated; NC-non-castrated, non-treated. At the end of treatment period (2 months), an intravenous glucose tolerance test (IVGTT) was performed in all rabbits.

RESULTS: Fasting blood glucose concentrations in FO and KO animals were significantly lower than in group C. The blood glucose concentrations in FO- and KO-treated animals returned to initial values after 30 and 60 min of IVGTT, respectively. In liver, carnitine palmitoyltransferase 2 (Cpt2) and 3-hydroxy-3-methyl-glutaryl-CoA synthase 2 (Hmgcs2) genes were significantly increased in FO-fed rabbits compared with the C group. Acetyl-CoA carboxylase alpha (Acaca) expression was significantly reduced in both KO- and FO-fed rabbits. In skeletal muscle, Hmgcs2 and Cd36 were significantly higher in KO-fed rabbits compared with the C group. Acaca expression was significantly lower in KO- and FO-fed rabbits compared with the C group.

CONCLUSION: The present results indicate that FO and KO supplementation decreases fasting blood glucose and improves glucose tolerance in obese New Zealand white rabbits. This could be ascribed to the ameliorated insulin sensitivity and insulin secretion and modified gene expressions of some key enzymes involved inβ-oxidation and lipogenesis in liver and skeletal muscle.

Study Type : Animal Study

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Sayer Ji
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