Flavonoid glycosides from seeds of Hippophae rhamnoides have α-glucosidase inhibition activity. - GreenMedInfo Summary

Hippophae rhamnoides subsp. Sinensis is a famous traditional medicinal plant in Tibet and Mongolia of China. Three novel flavonoid glycosides and ten known analogues were obtained from the seeds of H. rhamnoides. The structures of new compounds were elucidated by spectroscopics, chemical methods as well as literature data. In vitro assay, compounds 5-9, kaempferol and 70% ethanolic elution fraction showed prominentα-glucosidase inhibitory activities with ICvalues ranging from 8.30 to 112.11 μM, better than that of the positive control, acarbose, whose ICvalue was 1727.07 μM.