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Article Publish Status: FREE
Abstract Title:

The Flavonoid Jaceosidin fromInduces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells.

Abstract Source:

Evid Based Complement Alternat Med. 2018 ;2018:5765047. Epub 2018 May 13. PMID: 29861773

Abstract Author(s):

Hye-Yeon Han, Hyung Joon Kim, Seung-Hwa Jeong, Jiyeon Kim, Sung-Hee Jeong, Gyoo Cheon Kim, Dae-Seok Hwang, Uk-Kyu Kim, Mi Heon Ryu

Article Affiliation:

Hye-Yeon Han

Abstract:

Jaceosidin is a single compound from the Japanese mugwort, which is used as a food and a traditional medicinal herb.extracts and flavonoid components have been shown to have antihyperglycaemic, antioxidant, and anti-inflammatory properties. Although the anticancer properties of these extracts were recently demonstrated, the related mechanisms have not been characterised. In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC= 82.1 M in HSC-3 cells and 97.5 M in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle. In addition, jaceosidin increased cleavage of caspase-9 and caspase-3 in OSCC cells, although caspase-8 was not detected. In further experiments, jaceosidin downregulated Akt phosphorylation and ectopic activation of Akt blocked the antiproliferative effects of jaceosidin. Finally, we showed that jaceosidin has no effects on HaCaT normal epithelial cell viability, indicating selective chemotherapeutic potential of jaceosidin and that tumour-specific downregulation of Akt increases apoptosis and inhibits growth in OSCC cells.

Study Type : In Vitro Study

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