Flaxseed oil ameliorates mercuric chloride-induced liver damage. - GreenMedInfo Summary
Flaxseed oil ameliorates mercuric chloride-induced liver damage in rats.
J Trace Elem Med Biol. 2022 Feb 25 ;71:126965. Epub 2022 Feb 25. PMID: 35278998
Tareq Nayef AlRamadneh
BACKGROUND: Mercury is a relentless pollutant, and its toxicity contributes to significant health problems due to exposure to the environment. The present study has determined the impact of flaxseed oil on mercuric chloride (HgCl)-mediated hepatic oxidative toxicity in rats.
METHODS: Twenty-four healthy male Wistar rats were divided into four groups with six animals in each group. Group-A was the Control group treated with saline; Group-B received 1.0 ml oral dosage of flaxseed oil; Group-C was given 200 µl intraperitoneal injection of HgCland Group-D received 1.0 ml oral dosage of flaxseed oil (one hour after treatment with 200 µl intraperitoneal injection of HgCl.
RESULTS: Mercuric chloride (HgCl) increased the production of malondialdehyde (MDA), reactive oxygen species (ROS), glutathione (GSH), and the concentration of HgClin the liver tissue with a simultaneous decrease in the activities of Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Furthermore, serum HgClelevated the activity of alanine transaminase (ALT) and Lactate dehydrogenase (LDH). Histopathological changes showed that liver injury was caused by mercuric chloride. Treatment with flaxseed oil ameliorated ROS production and reversed enzymes in serum and liver. Also, a noticeable improvement was observed in all the histopathological characteristics in the rats.
CONCLUSIONS: The findings of this study concluded that flaxseed oil had an outstanding remedial effect on mercuric chloride-mediated hepatic cytotoxicity.