Abstract Title:

Evaluation of Fluoride-Induced Oxidative Stress in Rat Brain: A Multigeneration Study.

Abstract Source:

Biol Trace Elem Res. 2010 Jul 24. Epub 2010 Jul 24. PMID: 20658207

Abstract Author(s):

P Mahaboob Basha, Puja Rai, Shabana Begum

Article Affiliation:

Bangalore University, Bangalore, India, [email protected]


Multigenerational evaluation was made in rats on exposure to high fluoride (100 and 200 ppm) to assess neurotoxic potential of fluoride in discrete areas of the brain in terms of lipid peroxidation and the activity of antioxidant enzyme system. The rats were given fluoride through drinking water (100 and 200 ppm) and maintained subsequently for three generations. Fluoride treatment significantly increased the lipid peroxidation and decreased the activity of antioxidant enzymes viz, catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione level in first-generation rats and these alterations were more pronounced in the subsequent second and third-generation rats in both the doses tested. Decreased feed and water consumption, litter size and organ (brain) somatic index, marginal drop in body growth rate and mortality were observed in all three generations. Decreased antioxidant enzyme activity and increased malondialdehyde levels found in the present study might be related to oxidative damage that occurs variably in discrete regions of the brain. Results of this study can be taken as an index of neurotoxicity in rats exposed to water fluoridation over several generations.

Study Type : Animal Study
Additional Links
Problem Substances : Fluoride : CK(565) : AC(152)
Adverse Pharmacological Actions : Neurotoxic : CK(2424) : AC(562)

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