The freeze-dried powder ofMiquel ameliorated the isoproterenol-induced oxidative stress and tissue damage in rats.
J Microbiol Biotechnol. 2021 Jun 30 ;31. Epub 2021 Jun 30. PMID: 34226405
Jin Tae Kim
Miquel (), a Korean black raspberry, is known to possess various phytochemicals exerting the effect on oxidation, inflammation, and cancer. However, most of studies have been performed with the solvent extracts and/or the single component to demonstrate the efficacy, and the study evaluating the effect of the whole fructus ofMiquel is limited. In this study, therefore, we employed the isoproterenol (IPN)-induced myocardial infarction model and investigated the effect of freeze-dried powder ofMiquel (RCP) on oxidative stress and protection of organ damage. Oral administration of RCP reduced the level of toxicity markers, alanine transaminase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) without affecting the body weight and diet intake. The oxidative stress marker glutathione (GSH) increased about 45% and malonaldehyde (MDA) decreased about 27% compared to the IPN group by RCP-H (3%) administration. In histological analysis, IPN induced significant myocardial damage in the heart and vascular injury in the liver, and RCP administration ameliorated the damages in a dose-dependent manner. Taken together, RCP activated the antioxidant system leading to the organ protection damaged by IPN in rats, making it possible to expect the beneficial efficacies by consuming the whole fructus ofMiquel.