Abstract Title:

Reduced neurogenesis in the rat hippocampus following high fructose consumption.

Abstract Source:

Regul Pept. 2011 Feb 25 ;167(1):26-30. Epub 2010 Nov 27. PMID: 21115071

Abstract Author(s):

Karin van der Borght, Rickard Köhnke, Nathanael Göransson, Tomas Deierborg, Patrik Brundin, Charlotte Erlanson-Albertsson, Andreas Lindqvist

Article Affiliation:

Neuronal Survival Unit, Department of Experimental Medical Science, BMC A10, Lund University, Lund, Sweden.


In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study addto the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks.

Study Type : Animal Study

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