Article Publish Status: FREE
Abstract Title:

Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.

Abstract Source:

BMC Nephrol. 2018 11 8 ;19(1):315. Epub 2018 Nov 8. PMID: 30409184

Abstract Author(s):

Richard J Johnson, Santos E Perez-Pozo, Julian Lopez Lillo, Felix Grases, Jesse D Schold, Masanari Kuwabara, Yuka Sato, Ana Andres Hernando, Gabriela Garcia, Thomas Jensen, Christopher Rivard, Laura G Sanchez-Lozada, Carlos Roncal, Miguel A Lanaspa

Article Affiliation:

Richard J Johnson


BACKGROUND: Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation.

METHODS: We analyzed a previously published randomized controlled study that included 33 healthy male adults (40-65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. Participants were evaluated at the Unit of Nephrology of the Mateo Orfila Hospital in Menorca. Changes in serum levels of magnesium, calcium, uric acid, phosphorus, vitamin D, andintact PTH levels were evaluated. Urine magnesium, calcium, uric acid, phosphorus, citrate, oxalate, sodium, potassium, as well as urinary pH, were measured.

RESULTS: Ingestion of fructose was associated with an increased serum level of uric acid (p < 0.001), a decrease in serum ionized calcium (p = 0.003) with a mild increase in PTH (p < 0.05) and a drop in urinary pH (p = 0.02), an increase in urine oxalate (p = 0.016) and decrease in urinary magnesium (p = 0.003).

CONCLUSIONS: Fructose appears to increase urinary stone formation in part via effects on urate metabolism and urinary pH, and also via effects on oxalate. Fructose may be a contributing factor for the development of kidney stones in subjects with metabolic syndrome and those suffering from heat stress.

TRIAL REGISTRATION: ClinicalTrials.gov NCT00639756 March 20, 2008.

Study Type : Animal Study

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