Abstract Title:

[Inhibition of fructose-induced hyperuricacidemia by pretreatment with phosphates].

Abstract Source:

Boll Soc Ital Biol Sper. 1982 Apr 30;58(8):491-6. PMID: 7093059

Abstract Author(s):

G Morozzi, C Berti, R Pellegrini, M Lalumera, R Marcolongo


To test the hypothesis that intravenous injections of fructose rapidly decreases liver ATP and Pi and results in the rapid degradation of adenine nucleotides and hyperuricemia, fructose was administered intravenously to a group of normal and gouty subjects; 4 gouty patients were treated with a phosphate solution prior fructose loading. The results obtained show that fructose administration plus phosphate solution prevents Pi depletion and inhibits fructose-induced hyperuricemia.

Study Type : Human Study

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