n/a
Abstract Title:

Fucoxanthin Inhibitsβ-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments.

Abstract Source:

J Agric Food Chem. 2017 May 24 ;65(20):4092-4102. Epub 2017 May 11. PMID: 28478680

Abstract Author(s):

Siying Xiang, Fufeng Liu, Jiajia Lin, Huixin Chen, Chunhui Huang, Liping Chen, Yiying Zhou, Luying Ye, Ke Zhang, Jiukai Jin, Jiacheng Zhen, Chuang Wang, Shan He, Qinwen Wang, Wei Cui, Jinrong Zhang

Article Affiliation:

Siying Xiang

Abstract:

β-Amyloid (Aβ) can form aggregates through self-assembly and produce neurotoxicity in the early stage of Alzheimer's disease (AD). Therefore, the inhibition of Aβ assembly is considered as the primary target for AD therapy. In this study, we reported that fucoxanthin, a marine carotenoid, potently reduced the formation of Aβ fibrils and oligomers. Moreover, the fucoxanthin-triggered modification significantly reduced the neurotoxicity of Aβ oligomers in vitro. Molecular dynamics simulation analysis further revealed a hydrophobic interaction between fucoxanthin and Aβ peptide, which mightprevent the conformational transition and self-assembly of Aβ. Most importantly, fucoxanthin could attenuate cognitive impairments in Aβ oligomer-injected mice. In addition, fucoxanthin significantly inhibited oxidative stress, enhanced the expression of brain-derived neurotrophic factor, and increased ChAT-positive regions in the hippocampus of mice. On the basis of these novel findings, we anticipated that fucoxanthin might ameliorate AD via inhibiting Aβ assembly and attenuating Aβ neurotoxicity.

Study Type : Animal Study, In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.