Article Publish Status: FREE
Abstract Title:

Fucoxanthin-rich fraction fromalleviates particulate matter-induced inflammationand.

Abstract Source:

Toxicol Rep. 2021 ;8:349-358. Epub 2021 Feb 6. PMID: 33665132

Abstract Author(s):

Yu-Lin Dai, Yun-Fei Jiang, Yu-An Lu, Jiang-Bo Yu, Min-Cheol Kang, You-Jin Jeon

Article Affiliation:

Yu-Lin Dai


Particulate matter (PM) contributes to air pollution and primarily originates from unregulated industrial emissions and seasonal natural dust emissions. Fucoxanthin (Fx) is a marine natural pigment from brown macroalgae that has been shown to have various beneficial effects on health. However, the effects of Fx on PM-induced toxicities in cells and animals have not been assessed. In this study, we investigated the anti-inflammatory potential of the Fx-rich fraction (FxRF) ofagainst PM-mediated inflammatory responses. The FxRF composition was analyzed by rapid-resolution liquid chromatography mass spectrometry. Fx and other main pigments were identified. FxRF attenuated the production of inflammatory components, including prostaglandin E2 (PGE), cyclooxygenase-2, interleukin (IL)-1β, and IL-6 from PM-exposed HaCaT keratinocytes. PM exposure also reduced the levels of nitric oxide (NO), tumor necrosis factor-α, inducible nitric oxide synthase (iNOS), and PGEin PM-exposed RAW264.7 macrophages. Additionally, the culture medium from PM-exposed HaCaT cells induced upregulation of NO, iNOS, PGE, and pro-inflammatory cytokines in RAW264.7 macrophages. FxRF also significantly decreased the expression levels of factors involved in inflammatory responses, such as NO, reactive oxygen species, and cell death, in PM-exposed zebrafish embryos. These results demonstrated the potential protective effects ofFxRF against PM-induced inflammation bothand in a zebrafish model.

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