Furanodiene: A novel, potent and multitarget cancer-fighting terpenoid. - GreenMedInfo Summary
Furanodiene: A novel, potent and multitarget cancer-fighting terpenoid.
Curr Pharm Des. 2021 Feb 11. Epub 2021 Feb 11. PMID: 33573548
Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product which is isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Although furanodiene has been systematically studied for its anti-cancer potential, however, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.