Feasibility of Using Seaweed () Synbiotic as a Bioactive Material for Intestinal Health.
Foods. 2019 Nov 27 ;8(12). Epub 2019 Nov 27. PMID: 31783694
The market contains only limited health care products that combine prebiotics and probiotics. In this study, we developed a seaweed-basedsynbiotic and verified the efficacy by small intestinal cells (Caco-2). We also developed a functional material that promotes intestinal health and prevents intestinal inflammation.was used as a red seaweed prebiotic, and,subsp.,subsp.,, andsubsp.were mixed for the seaweed's synbiotics.synbiotics were nontoxic to Caco-2 cells, and the survival rate was 101% to 117% for a multiplicative effect on cell survival. After cells were induced by HO, the levels of reactive oxygen species (ROS) increased to 151.5%, but aftersynbiotic treatment, decreased to a range between 101.8% and 109.6%. After cells were induced by tumor necrosis factorα, the ROS levels increased to 124.5%, but decreased to 57.7% withtreatment.synbiotics could effectively inhibit the production of ROS intestinal cells under oxidative stress (induced by HOand tumor necrosis factorα (TNF-α)), which can reduce the damage of cells under oxidative stress. Functioning of intestinal cells could be improved by inhibiting the production of inflammatory factor substances (interleukin 8) withsymbiotic treatment. Also, gastrointestinal diseases may be retarded by a synbiotic developed fromto promote intestinal health and prevent intestinal inflammation.