Abstract Title:

Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance.

Abstract Source:

mSystems. 2020 Jan 14 ;5(1). Epub 2020 Jan 14. PMID: 31937680

Abstract Author(s):

Philip J Richards, Geraldine M Flaujac Lafontaine, Phillippa L Connerton, Lu Liang, Karishma Asiani, Neville M Fish, Ian F Connerton

Article Affiliation:

Philip J Richards


Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides (GOS) in broiler feed enhanced the growth rate and feed conversion of chickens relative to those obtained with a calorie-matched control diet. Comparison of the cecal microbiota identified key differences in abundances ofspp. Increased levels ofin GOS-fed juvenile birds at the expense ofwere linked to improved performance (growth rate and market weight). Investigation of the innate immune responses highlighted increases of ileal and cecal interleukin-17A (IL-17A) gene expression counterposed to a decrease in IL-10. Quantification of the autochthonousspp. revealed a correlation between bird performance andabundance. Shifts in the cecal populations of keyspp. of juvenile birds primed intestinal innate immunity without harmful pathogen challenge.Improvements in the growth rate of broiler chickens can be achieved through dietary manipulation of the naturally occurring bacterial populations while mitigating the withdrawal of antibiotic growth promoters. Prebiotic galacto-oligosaccharides (GOS) are manufactured as a by-product of dairy cheese production and can be incorporated into the diets of juvenile chickens to improve their health and performance. This study investigated the key mechanisms behind this progression and pinpointedas a key species that facilitates the enhancements in growth rate and gut health. The study identified the relationships between the GOS diet,intestinal populations, and cytokine immune effectors to improve growth.

Study Type : Animal Study

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