Galectin-3 inhibition with modified citrus pectin in hypertension. - GreenMedInfo Summary
Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension.
JACC Basic Transl Sci. 2021 Jan ;6(1):12-21. Epub 2021 Jan 6. PMID: 33532663
Emily S Lau
We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation.