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Abstract Title:

Gambogic Acid as a Candidate for Cancer Therapy: A Review.

Abstract Source:

Int J Nanomedicine. 2020 ;15:10385-10399. Epub 2020 Dec 22. PMID: 33376327

Abstract Author(s):

Yuling Liu, Yingchong Chen, Longfei Lin, Hui Li

Article Affiliation:

Yuling Liu

Abstract:

Gambogic acid (GA), a kind of dry resin secreted by thetree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

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