Abstract Title:

Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells by inducing autophagy and downregulating β‑catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T‑ALL cells.

Abstract Source:

Oncol Rep. 2020 Oct ;44(4):1747-1757. Epub 2020 Aug 11. PMID: 32945501

Abstract Author(s):

Tongtong Wang, Jing Du, Dexia Kong, Guosheng Yang, Qihao Zhou, Fei You, Yan Lin, Ying Wang

Article Affiliation:

Tongtong Wang


The main active compound of Garcinia hanburyi (referred to as gamboge) is gambogic acid (GA), which has long been a Chinese herbal medicine for treating several types of cancer. However, the potential therapeutic role and mechanisms of GA in T‑cell acute lymphoblastic leukemia (T‑ALL) remain unclear. In the present study, the effects of GA on proliferation, cell cycle, apoptosis, and autophagy in T‑ALL cell lines were investigated. The possible mechanisms underlying GA activity were also examined. The results showed that GA inhibited proliferation, induced apoptosis, and activated autophagy in T‑ALL cell lines (Jurkat and Molt‑4 cells). Findings confirmed that GA has an antileukemia effect against peripheral blood lymphocyte cells in patients with ALL. GA inhibited phospho‑GSK3β S9 (p‑GSK3β S9) protein levels to inactivate Wnt signaling and suppress β‑catenin protein levels. In addition, the inhibitory effect of GA on T‑ALL was reversed by overexpression of β‑catenin. Thus, GA can inhibit the growth and survival of T‑ALL cells. GA also had antileukemic activity, at least in part, through the downregulation of the Wnt/β‑catenin signaling pathway.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.