Abstract Title:

γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice.

Abstract Source:

Nutrients. 2019 Mar 31 ;11(4). Epub 2019 Mar 31. PMID: 30935111

Abstract Author(s):

Wiramon Rungratanawanich, Giovanna Cenini, Andrea Mastinu, Marc Sylvester, Anne Wilkening, Giulia Abate, Sara Anna Bonini, Francesca Aria, Mariagrazia Marziano, Giuseppina Maccarinelli, Maurizio Memo, Wolfgang Voos, Daniela Uberti

Article Affiliation:

Wiramon Rungratanawanich


Rice (L.) is the richest source ofγ-oryzanol, a compound endowed with antioxidant and anti-inflammatory properties. γ-Oryzanol has been demonstrated to cross the blood-brain barrier in intact form and exert beneficial effects on brain function. This study aimed to clarify the effects of γ-oryzanol in the hippocampus in terms of cognitive function and protein expression. Adult mice were administered with γ-oryzanol 100 mg/kg or vehicle (control) once a day for 21 consecutive days following which cognitive behavior and hippocampal proteome were investigated. Cognitive tests using novel object recognition and Y-maze showed that long-term consumption of γ-oryzanol improves cognitive function in mice. To investigate the hippocampal proteome modulated by γ-oryzanol, 2D-difference gel electrophoresis (2D-DIGE) was performed. Interestingly, we found that γ-oryzanol modulates quantitative changes of proteins involved in synaptic plasticity and neuronal trafficking, neuroprotection and antioxidant activity, and mitochondria and energy metabolism. These findings suggested γ-oryzanol as a natural compound able to maintain and reinforce brain function. Although more intensive studies are needed, we propose γ-oryzanol as a putative dietary phytochemical for preserving brain reserve, the ability to tolerate age-related changes, thereby preventing clinical symptoms or signs of neurodegenerative diseases.

Study Type : Animal Study

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