Abstract Title:

Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice.

Abstract Source:

Int J Biol Macromol. 2016 May 18. Epub 2016 May 18. PMID: 27208798

Abstract Author(s):

Ming-Zi Ouyang, Li-Zhu Lin, Wen-Jiao Lv, Qian Zuo, Zhuo Lv, Jie-Shan Guan, Shu-Tang Wang, Ling-Ling Sun, Han-Rui Chen, Zhi-Wei Xiao

Article Affiliation:

Ming-Zi Ouyang


The weight-loaded swimming capability, tumor growth, survival time and biochemical markers of Ganoderma lucidum polysaccharides (GLPs) in a chemotherapy-related fatigue mouse model were tested in the present study. The results showed that the middle-dose GLPs(GLP-M) and the high-dose GLPs(GLP-H) could increase the exhausting swimming time, which was observed to decrease in the cisplatin control group(PCG) and the tumor control group(TCG).The GLP-M and the GLP-H had reduced serum levels of tumor necrosis factor-αand interleukin-6, which were up-regulated by cisplatin. Cisplatin and the presence of tumor significantly enhanced the malondialdehyde(MDA) content and inhibited the activity of superoxide dismutase(SOD) in the muscle. Administration of GLPs at a high dose decreased the levels of MDA and up-regulated the SOD activity. The high-dose GLPs+cisplatin group presented a decreased tendency of tumor volume and a lower tumor weight compared with PCG. Moreover, the mice in the GLP-M and GLP-H groups had longer survival times compared with the mice in the TCG and PCG.The levels of creatinine and serumblood urea nitrogen, which are up-regulated by cisplatin, were significantly reduced by GLP-M and GLP-H. Therefore, these results suggest that GLPs might improve chemotherapy-related fatigue via regulation of inflammatory responses, oxidative stress and reduction of nephrotoxicity.

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