Garcixanthone E and garcimangophenone C: new metabolites from Garcinia mangostana and their cytotoxic and alpha amylase inhibitory potential. - GreenMedInfo Summary
Garcixanthone E and Garcimangophenone C: New Metabolites fromand Their Cytotoxic and Alpha Amylase Inhibitory Potential.
Life (Basel). 2022 Nov 14 ;12(11). Epub 2022 Nov 14. PMID: 36431010
Gamal A Mohamed
(Clusiaceae) is a rich pool of metabolites with diversified bioactivities. A new xanthone, garcixanthone E (), and a new benzophenone, rhamnoside, as well as garcimangophenone C () together with garcinone E (),α-mangostin (),γ-mangostin (), garcinone C (), garcixanthone C (), gartanin (), and 2,4,6,3',5'-pentahydroxybenzophenone () were purified fromEtOAc extract. Their structural verification was accomplished utilizing assorted spectral tools and relating to the literature. The in vitro cytotoxic potential versus MCF-7, A549, and HCT-116 cell lines demonstrated the moderate potential of(ICs 8.5, 5.4, and 5.7µM, respectively) in comparison to doxorubicin (ICs 0.18, 0.6 and 0.2µM, respectively) using a sulforhodamine B (SRB) assay. Additionally,andhad AAI (α-amylase inhibition) with ICs 17.8 and 12.9µM, respectively, compared to acarbose (IC6.7µM). Further, their AAI mechanisms were inspected utilizing molecular-docking evaluation by employing the crystal structure of the humanα-amylase (PDB-ID: 5EOF). Compoundpossessed a reasonable docking score of -7.746 kcal/mol compared with the native ligandwhich had a docking score of -9.932 kcal/mol. These results could further provide new insight into the potential usage ofas a functional food for regulating postprandial hyperglycemia via suppressing AA.