Article Publish Status: FREE
Abstract Title:

Garlic (L.) Bioactives and Its Role in Alleviating Oral Pathologies.

Abstract Source:

Antioxidants (Basel). 2021 Nov 21 ;10(11). Epub 2021 Nov 21. PMID: 34829718

Abstract Author(s):

Minnu Sasi, Sandeep Kumar, Manoj Kumar, Sandhya Thapa, Uma Prajapati, Yamini Tak, Sushil Changan, Vivek Saurabh, Shweta Kumari, Ashok Kumar, Muzaffar Hasan, Deepak Chandran, Radha, Sneh Punia Bangar, Sangram Dhumal, Marisennayya Senapathy, Anitha Thiyagarajan, Ahmad Alhariri, Abhijit Dey, Surinder Singh, Suraj Prakash, Ravi Pandiselvam, Mohamed Mekhemar

Article Affiliation:

Minnu Sasi


Garlic (L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases.

Study Type : Review

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