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Abstract Title:

GC-MS Profiling and Antineoplastic Activity of Pelargonium Inquinans Ait Leaves on Acute Leukaemia Cell Lines U937 and Jurkat.

Abstract Source:

Nutr Cancer. 2021 Sep 3:1-23. Epub 2021 Sep 3. PMID: 34477039

Abstract Author(s):

Ogochukwu Izuegbuna, Gloria A Otunola, Graeme Bradley

Article Affiliation:

Ogochukwu Izuegbuna

Abstract:

We investigated the antineoplastic activities of extracts ofleaves, a plant native to South Africa on acute leukemia cell lines, U937 and Jurkat and the inflammatory effect (nitric oxide and cyclo-oxygenase-2) on RAW 264.7 cells. The extracts ofhave significant cytotoxicity especially on U937 cells and pro-inflammatory release of nitric oxide on RAW 264.7 macrophages. The GC-MS study of the essential oil showed it had more than a hundred compounds. This study showed thathave antineoplastic and anti-inflammatory activities which can be further explored in In Vivo studies.

Study Type : In Vitro Study

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