Article Publish Status: FREE
Abstract Title:

Protective Effects of Genipin on Gastrointestinal Disorders.

Abstract Source:

Biol Pharm Bull. 2017 ;40(2):151-154. PMID: 28154253

Abstract Author(s):

Yoon Ah Sohn, In Young Hwang, Sun Yi Lee, Hyo Sun Cho, Choon Sik Jeong

Article Affiliation:

Yoon Ah Sohn


Genipin, an aglycone of geniposide, is a major component of gardeniae fructus, and has been used to treat jaundice, various inflammatory disorders, and liver disease, and has also been used as a natural cross-linking agent. The authors conducted several experiments to evaluate the protective effects of genipin on gastrointestinal disorders, such as, gastritis and gastric ulcers. Genipin showed inhibitory effects against HCl·ethanol-induced acute gastritis and indomethacin-induced gastric ulcers in rats and increased prostaglandin E(PGE) in AGS gastric cancer cell. Genipin had significant effects on aggressive factors, acid-neutralization, and gastric secretion, and inhibited H/K-ATPase (a proton pump), which secretes gastric acid. The results obtained indicate that genipin has significant gastroprotective effects and might be useful for treating and preventing gastric lesions.

Study Type : Animal Study

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