Article Publish Status: FREE
Abstract Title:

Genistein treatment increases bone mass in obese, hyperglycemic mice.

Abstract Source:

Diabetes Metab Syndr Obes. 2016 ;9:63-70. Epub 2016 Mar 15. PMID: 27042131

Abstract Author(s):

Richard M Michelin, Layla Al-Nakkash, Tom L Broderick, Jeffrey H Plochocki

Article Affiliation:

Richard M Michelin


BACKGROUND: Obesity and type 2 diabetes mellitus are associated with elevated risk of limb bone fracture. Incidences of these conditions are on the rise worldwide. Genistein, a phytoestrogen, has been shown by several studies to demonstrate bone-protective properties and may improve bone health in obese type 2 diabetics.

METHODS: In this study, we test the effects of genistein treatment on limb bone and growth plate cartilage histomorphometry in obese, hyperglycemic ob/ob mice. Six-week-old ob/ob mice were divided into control and genistein-treated groups. Genistein-treated mice were fed a diet containing 600 mg genistein/kg for a period of 4 weeks. Cross-sectional geometric and histomorphometric analyses were conducted on tibias.

RESULTS: Genistein-treated mice remained obese and hyperglycemic. However, histomorphometric comparisons show that genistein-treated mice have greater tibial midshaft diameters and ratios of cortical bone to total tissue area than the controls. Genistein-treated mice also exhibit decreased growth plate thickness of the proximal tibia.

CONCLUSION: Our results indicate that genistein treatment affects bone of the tibial midshaft in the ob/ob mouse, independent of improvements in the hyperglycemic state and body weight.

Study Type : Animal Study

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