Abstract Title:

Radioprotective activity of Gentiana lutea extract and mangiferin.

Abstract Source:

Phytother Res. 2010 Nov;24(11):1693-6. PMID: 21031630

Abstract Author(s):

Nebojsa Menkovic, Zorica Juranic, Tatjana Stanojkovic, Tatjana Raonic-Stevanovic, Katarina Savikin, Gordana Zdunić, Nenad Borojevic

Article Affiliation:

Institute for Medicinal Plants Research, Tadeusa Koscuska 1, Belgrade, 11000 Serbia.


Radioprotective/sensitizing actions of Gentiana lutea aqueous-ethanol extract and mangiferin on radiation-induced effects on different types of cells were investigated. The study focused on the decreasing survival of normal human immunocompetent cells, the survival of the malignant cells in vitro, and the survival of ex vivo irradiated cells before and after consumption of the extract by healthy volunteers. The in vitro experiments showed that mangiferin could inhibit cytotoxic action of ionizing irradiation (doses of 6 and 8 Gy) only on normal resting human PBMC, not stimulated for proliferation. Orally consumed G. lutea extract showed the potential to reduce the cytotoxic effect of x-ray irradiation on normal human immunocompetent cells PBMC of some healthy people, without changing the susceptibility of malignant cells to be destroyed by irradiation. Since the radioprotective effect was individually dependent, further clinical studies are needed.

Study Type : In Vitro Study

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