Article Publish Status: FREE
Abstract Title:

Reconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts.

Abstract Source:

Sci Rep. 2014 Feb 4 ;4:3962. Epub 2014 Feb 4. PMID: 24492623

Abstract Author(s):

Hao Chen, Lei Cheng, Xiaoli Lin, Xiaping Zhou, Zhiming Cai, Ming Li

Article Affiliation:

Hao Chen


Chronic coronary heart disease (cCHD) is characterized by atherosclerosis, which progressively narrows the coronary artery lumen and impairs myocardial blood flow. Restoration of occluded coronary vessels with newly formed collaterals remains an ideal therapeutic approach due to the need for redirecting blood flow into the ischemic heart. In this study, we investigated the effect of an active fraction isolated from Geum joponicum (AFGJ) on angiogenesis in cCHD hearts. Our results demonstrated that AFGJ not only enhanced capillary tube formation of endothelial cells, but also promoted the growth of new coronary collaterals (at the diameter 0.021-0.21 mm) in the ischemic region of hearts in rat cCHD model. Our study also indicated that the growth of new collaterals in ischemic hearts resulted in improved functional recovery of the cCHD hearts as demonstrated by ECG and echocardiography analyses. These data suggest that AFGJ may provide a noveltherapeutic method for effective treatment of cCHD.

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