Abstract Title:

Protective effects of serum containing Ginkgo biloba extract on glomerulosclerosis in rat mesangial cells.

Abstract Source:

J Ethnopharmacol. 2009 Jul 6;124(1):26-33. Epub 2009 Apr 16. PMID: 19375492

Abstract Author(s):

Daoquan Tang, Zunjian Zhang, Yuanyuan Gao, Yaqin Wei, Lin Han


ETHNOPHARMACOLOGICAL RELEVANCE: Ginkgo biloba extract (GBE) is an ancient Chinese phytomedicine which was used to treat various ailments including circulatory and demential disorders. AIM OF THE STUDY: To study GBE's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells by serum pharmacological methods. MATERIALS AND METHODS: The cultured mesangial cells were divided into seven groups: normal, solvent control, high glucose, low dose of GBE serum, moderate dose of GBE serum, high dose of GBE serum, and GBE. The activities of cell antioxidases, type IV collagen and laminin, Smad2/3 and Smad7, and TGF-beta(1) mRNA were measured by methods of spectrophotometry, radioimmunoassay, immunocytochemistry, and RT-PCR, respectively. RESULTS: The intensity of oxidative stress decreased in the GBE serum-treated groups in comparison with the high glucose group. In addition, the expression of Smad2/3 was greatly reduced, whereas Smad7 expression increased; type IV collagen, laminin and TGF-beta(1) mRNA levels were also diminished. CONCLUSION: These results suggest that GBE is protective agent against glomerulosclerosis in diabetic nephropathy of mesangial cells.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.