Abstract Title:

The preventive effect of ginkgo biloba extract in myringosclerosis: study in rats.

Abstract Source:

Int J Cancer. 2008 Jul 1;123(1):41-50. PMID: 19201283

Abstract Author(s):

Hatice Emir, Zeynep Kizilkaya Kaptan, Erdal Samim, Nuran Sungu, Kursat Ceylan, Huseyin Ustun

Article Affiliation:

Otorhinolaryngology Clinic, Ministry of Health, Ankara Training and Research Hospital, Turkey. [email protected]


OBJECTIVE: To determine the preventive effect of Ginkgo biloba extract in the formation of myringosclerosis.

STUDY DESIGN: Prospective, randomized clinical study.

MATERIALS AND METHODS: Posterosuperior quadrant of tympanic membranes of twenty-five Wistar Albino rats were bilaterally myringotomized. They were divided into three groups randomly. Groups 1 and 2 were administered 100 mg/kg/day and 200 mg/kg/day systemic Ginkgo biloba extract. The third group was treated with 1 mL/day saline solution. After 10 days of treatment, myringotomized membranes were examined by otomicroscopy and harvested. They were evaluated histopathologically by light microscopy and compared according to the occurrence of myringosclerotic plaques and the thickness of membranes.

RESULTS: Tympanic membranes of groups 1 and 2 nearly had no existence of myringosclerosis (72.2% in group 1 and 83.3% in group 2, P = 0.434). However, in group 3, only 14.3 percent had no myringosclerosis (P<0.001). Thickness of membranes in group 1 was 0.13 +/- 0.25, group 2 was 0.06 +/- 0.02, and group 3 was 0.19 +/- 0.35 mm. Group 3 had significantly thicker membranes compared with groups 1 and 2 (P<0.001 for group 2 and P = 0.003 for group 1).

CONCLUSION: Formation of experimental myringosclerosis was reduced or inhibited and tympanic membranes were thinner after systemic Ginkgo biloba extract administration.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.