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Article Publish Status: FREE
Abstract Title:

Ginseng polysaccharides: Potential antitumor agents.

Abstract Source:

J Ginseng Res. 2023 Jan ;47(1):9-22. Epub 2022 Jul 16. PMID: 36644386

Abstract Author(s):

Ruizhi Tao, Keqin Lu, Gangfan Zong, Yawen Xia, Hongkuan Han, Yang Zhao, Zhonghong Wei, Yin Lu

Article Affiliation:

Ruizhi Tao

Abstract:

As a famous herbal medicine in China and Asia, ginseng (Panax ginseng C. A. Meyer) is also known as the "King of All Herbs" and has long been used in medicine and healthcare. In addition to the obvious biological activities of ginsenosides, ginseng polysaccharides (GPs) exhibit excellent antitumor, antioxidant stress, and immunomodulatory effects. In particular, GPs can exert an antitumor effect and is a potential immunomodulator. However, due to the complexity and diversity in the structures and components of GPs, their specific physicochemical properties, and underlying mechanisms remain unclear. In this article, we have summarized the factors influencing the antitumor activity of GPs and their mechanism of action, including the stimulation of the immune system, regulation of the gut microbiota, and direct action on tumor cells.

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