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Abstract Title:

Ginseng stem-and-leaf saponins (GSLS)-enhanced Protective immune responses induced by Toxoplasma gondii heat shocked protein 70 (HSP70) against toxoplasmosis in mice.

Abstract Source:

J Parasitol. 2016 Nov 9. Epub 2016 Aug 9. PMID: 27828760

Abstract Author(s):

Xunhui Zhuo, Hongchao Sun, Suhua Wang, Xiaolu Guo, Haojie Ding, Yi Yang, Ying Shan, Aifang Du

Article Affiliation:

Xunhui Zhuo

Abstract:

Toxoplasma gondii is an obligate intracellular protozoan parasite and is able to infect birds and mammals including humans. In order to find effective antigen-adjuvant combinations that can boost the immunogenicity and protection of antigen vaccines against toxoplasmosis, we examined the protective efficacy in mice immunized with recombinant protein HSP70 when co-administered with ginseng stem-and-leaf saponins (GSLS) isolated from Panax ginseng. All immunized mice produced significantly high levels of specific antibodies against rTgHSP70 and splenocytes from mice presented strong proliferative immune responses. Vaccinated mice displayed a significantly increased percentage of CD4+ and CD8+ T cells indicating a strong immune response was triggered. The cellular and humoral immune responses were enhanced, which could be reflected by the increased mRNA levels of IFN-γ and IL-4 respectively. Immunization with rTgHSP70 and GSLS prolonged survival time of the treated mice compared to the controls which died within 6 days after challenge with the virulent T. gondii RH strain. Our data demonstrate that by addition with GSLS, rTgHSP70 induced a strong immune response and provided partial protection against T. gondii, therefore GSLS could be used as a promising vaccine adjuvant against acute toxoplasmosis.

Study Type : Animal Study

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