Ginsenoside Rb1 suppresses AOM/DSS-induced colon carcinogenesis. - GreenMedInfo Summary
Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis.
Anticancer Agents Med Chem. 2023 Jan 19. Epub 2023 Jan 19. PMID: 36655530
Ling Wang
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer world-wide. Current treatments, including surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance.
OBJECTIVE: Therefore, it is important to find additional therapies to combat the problem. Gin-senoside Rb1 is the main active ingredient of ginseng, which is a well-known herb in traditional Chinese medicine. Ginsenoside is reported to play an important role in the prevention and treatment of cancer.
METHODS: We established Azoxymethane (AOM)/Dextran sodium sulfate (DSS) colon cancer model based on inflammation, observed the beneficial effect of ginsenoside Rb1, and detected the changes in gut microbiota.
RESULTS: Our experimental results showed that gin-senoside Rb1 significantly reduced the levels of TNF-α, IL-6, IL-17A, IL-33, IL-1β, and IL-22, increased the level of IL-10, and also changed the gut microbiota composition. These results suggested that ginsenoside Rb1 can be used to prevent inflammation-associated CRC development and may provide an effective thera-peutic strategy for CRC by relieving chronic inflammation and restoring the gut microenvironment in the AOM/DSS-induced model of colitis-associated colorec-tal cancer in mice.
CONCLUSION: Ginsenoside Rb1 significantly attenuated AOM/DSS-induced colon carcinogenesis.