Article Publish Status: FREE
Abstract Title:

Ginsenoside Rc, an Active Component of, Alleviates Oxidative Stress-Induced Muscle Atrophy via Improvement of Mitochondrial Biogenesis.

Abstract Source:

Antioxidants (Basel). 2023 Aug 7 ;12(8). Epub 2023 Aug 7. PMID: 37627571

Abstract Author(s):

Aeyung Kim, Sang-Min Park, No Soo Kim, Haeseung Lee

Article Affiliation:

Aeyung Kim


Loss of skeletal muscle mass and function has detrimental effects on quality of life, morbidity, and mortality, and is particularly relevant in aging societies. The enhancement of mitochondrial function has shown promise in promoting muscle differentiation and function. Ginsenoside Rc (gRc), a major component of ginseng, has various pharmacological activities; however, its effect on muscle loss remains poorly explored. In this study, we examined the effects of gRc on the hydrogen peroxide (HO)-induced reduction of cell viability in C2C12 myoblasts and myotubes and HO-induced myotube degradation. In addition, we investigated the effects of gRc on the production of intracellular reactive oxygen species (ROS) and mitochondrial superoxide, ATP generation, and peroxisome proliferator-activated receptor-gamma co-activator 1α(PGC-1α) activity in myoblasts and myotubes under HOtreatment. Furthermore, to elucidate the mechanism of action of gRc, we conducted a transcriptome analysis of myotubes treated with or without gRc under HOtreatment. gRc effectively suppressed HO-induced cytotoxicity, intracellular ROS, and mitochondrial superoxide production, restored PGC-1αpromoter activity, and increased ATP synthesis. Moreover, gRc significantly affected the expression levels of genes involved in maintaining mitochondrial mass and biogenesis, while downregulating genes associated with muscle degradation in C2C12 myotubes under oxidative stress. We provide compelling evidence supporting the potential of gRc as a promising treatment for muscle loss and weakness. Further investigations of the pharmacological effects of gRc under various pathological conditions of muscle loss will contribute to the clinical development of gRc as a therapeutic intervention.

Study Type : In Vitro Study

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